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Year : 2021  |  Volume : 10  |  Issue : 4  |  Page : 210-214

Homocysteine and C-reactive protein levels in women with polycystic ovary syndrome

1 Department of Obstetrics and Gynecology, Ankara Training and Research Hospital, Ankara, Turkey
2 Department of Obstetrics and Gynecology, Adana City Hospital, Adana, Turkey
3 Department of Obstetrics and Gynecology, Ufuk University Medical Faculty, Ankara, Turkey
4 Department of Obstetrics and Gynecology, Ankara University Medical Faculty, Ankara, Turkey

Correspondence Address:
Dr. Murat Gozukucuk
Ministry of Health Ankara Training and Research Hospital, Ulucanlar Street. No: 89 Altindag, 06230 Ankara
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/GMIT.GMIT_30_20

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Objectives: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in infertile women characterized by both reproductive and metabolic dysfunctions of different degrees. Furthermore, it has been associated with increased cardiovascular disease (CVD) risk and related long-term health sequela. The aim of this study is to evaluate serum homocysteine (Hcy) and C-reactive protein (CRP) levels in women with PCOS and to evaluate their relationship with clinical and laboratory parameters in women with PCOS. Materials and Methods: The prospective single-center study included 45 women with PCOS (study group) and 41 control subjects. Demographic variables and Hcy, CRP, fasting blood glucose, insulin, follicle-stimulating hormone, luteinizing hormone, estradiol, total and free testosterone, dehydroepiandrosterone sulfate, thyroid-stimulating hormone levels, and lipid profiles of the subjects were recorded. homeostatic model assessment for insulin resistance (HOMA-IR) indexes were calculated. Results: Fasting plasma glucose, insulin, HOMA-IR, free and total testosterone levels, and clinical hirsutism were significantly higher in the study group. There was no statistically significant difference in lipid profile between groups. Hcy and CRP levels were higher in the study group, which was not statistically significantly different (P > 0.05). Conclusion: Some of the parameters that are correlated with CVD risk were found to be higher in women with PCOS, although the difference for Hcy and CRP did not reach statistical significance. However, the current study reveals that the CVD risk associated with PCOS deserves more comprehensive prospective studies with long-term outcomes.

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