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CLINICAL IMAGE
Year : 2022  |  Volume : 11  |  Issue : 2  |  Page : 131-133

Embolic microspheres observed during metroplasty


1 Department of Reproductive Medicine, IVIRMA Valencia, Valencia, Spain; Faculty of Medicine, University of Porto, Porto, Portugal
2 Department of Reproductive Medicine, IVIRMA Valencia, Valencia, Spain
3 Department of Reproductive Medicine, IVIRMA Valencia; Department of Pediatrics, Obstetrics and Gynecology, University of Valencia; IVI Foundation, Health Research Institute La Fe, Valencia, Spain
4 Department of Reproductive Surgery, IVIRMA Valencia, Valencia, Spain

Date of Submission19-May-2021
Date of Decision05-Oct-2021
Date of Acceptance09-Nov-2021
Date of Web Publication4-May-2022

Correspondence Address:
Dr. Pedro Brandao
Department of Reproductive Medicine, Instituto Valenciano de Infertilidad, Plaza de la Policía Local 3, Valencia

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/gmit.gmit_58_21

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How to cite this article:
Brandao P, Ceschin N, Bellver J, Ferro J. Embolic microspheres observed during metroplasty. Gynecol Minim Invasive Ther 2022;11:131-3

How to cite this URL:
Brandao P, Ceschin N, Bellver J, Ferro J. Embolic microspheres observed during metroplasty. Gynecol Minim Invasive Ther [serial online] 2022 [cited 2022 May 20];11:131-3. Available from: https://www.e-gmit.com/text.asp?2022/11/2/131/344793



Uterine leiomyomas are the most common gynecologic benign tumor. While numerous patients are asymptomatic, others present abnormal uterine bleeding, pelvic pain, or abdominal bulk. In addition, depending on number, size, and location, leiomyomas may impair fertility.

According to the Federation of Gynecology and Obstetrics nomenclature published in 2011, leiomyomas are classified based on their location in relation to the uterine wall (0–2 are predominantly submucous, 3–5 intramural, 6 and 7 subserous, and 8 a miscellaneous of other locations).[1]

Leiomyomas are usually diagnosed by pelvic ultrasound. Furthermore, magnetic resonance imaging may help mapping the distribution of the leiomyoma within the uterus, especially if they are large and numerous. In addition, depending on their location, hysteroscopy, or laparoscopy may lead to the diagnosis.[1]

Classically, leiomyomas are treated surgically. While combined contraceptive pills, Gonadotropin-releasing hormone agonists, and other hormonal modulators, such as ulipristal acetate, may temporarily control bleeding disorders and eventually lead to a small reduction in leiomyoma's size and volume, they do not provide a definitive treatment. Surgical treatments, on the other hand, provide a definitive solution, but are more invasive and may compromise future fertility. Theoretically, myomectomies may restore uterine anatomy, improving reproductive outcomes. However, depending on the size, number and location of the tumors, as well as the skills of the surgeon, it may not be possible to restore a functional cavity and there is a risk of ending up in a hysterectomy.

Uterine artery embolization (UAE) is being used for the last years to treat symptomatic uterine leiomyoma with promising results. In spite of being benign, leiomyomas are highly vascularized, hence presumably the blockage of their blood supply would induce necrosis and regression of the tumor.[2]

Fertility after this procedure is a major concern, especially regarding its potential harmful effect on ovarian reserve (due to possible involvement of the ovarian blood supply) and the commitment of the uterine irrigation itself, which may compromise not only the endometrium but also placental supply during pregnancy. Until date, scientific evidence on the effect of this technique on female fertility is still sparse.[3]

The technique consists on the blockage of the uterine artery with embolic agents, usually through catheterization of the femoral or radial arteries. There are three main different types of agents that can be used to perform this technique: Gelatin sponge, nonspherical polyvinyl alcohol particles, and calibrated microspheres such as tris-acryl gelatin microspheres. The first ones are cheaper and usually reabsorbed within 4–6 weeks. Microspheres, in turn, cause a more selective occlusion of the perifibroid plexuses, sparing the main and proximal branches, thus theoretically providing a better option if fertility is to be preserved. The classical microspheres are nonabsorbable, in contrast to gelatin sponges. Although the safety, efficacy, and performance of permanent embolic agents are well established, there may be still some concerns regarding the introduction of a permanent foreign body. Thus, more recently degradable microspheres have been developed. Despite these differences between the diverse embolic agents, there is no evidence of distinct efficacy, safety, or reproductive outcomes.[2],[4],[5]

A 41-year-old female patient came to our clinic due to primary infertility of 2 years, in search of pregnancy with donated sperm. She had been submitted to UAE due to symptomatic leiomyomas 6 years before. Furthermore, she reported having 2 previous Intracytoplasmic sperm injection (ICSI) cycles in other centers with recurrent implantation failure (a total of 6 good quality blastocysts transferred). According to the patient, embryos were of good quality but the endometrial lining was always thin on ultrasound, both in natural, stimulated, or hormonally replaced cycles. On infertility workup, she was diagnosed poor ovarian reserve based on low antral follicle count and anti- Müllerian hormone levels. In addition, pelvic ultrasound revealed a heterogeneous uterine wall with disperse hyperechogenic foci all over the myometrium [Figure 1]. Three-dimensional ultrasound raised the suspicion of a “T-shape” uterine cavity. The Endometrial Receptivity Analysis-ERA® test revealed a prereceptive endometrium, the window of implantation was so displaced that a new test was needed to confirm findings. Given these findings, the patient was proposed to hysteroscopic metroplasty.
Figure 1: Two-dimensional pelvic ultrasound revealing a heterogeneous uterine wall, with disperse hyperechogenic foci all over the myometrium (white arrows)

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During hysteroscopy, a “T-shape” cavity was observed, with a narrow body and widely separated deep tubal ostia. At first site, adenomyosis was suspected due to the presence of fibrotic adhesions of the fundus. When sectioning the uterine walls to amplify the cavity and correct the defect, abundant fibrosis was noted [Figure 2] and disperse greenish smooth spheres, with 5 mm of diameter were present within the fibrotic tissue and the myometrium [Figure 3] and [Figure 4].
Figure 2: (a) Uterine cavity overview during metroplasty. Fibrotic tissue may be seen in uterine walls (white arrows). (b) Magnification of the sectioned left uterine wall, with disperse greenish smooth small spheres (black arrows) within the fibrotic tissue (white arrows)

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Figure 3: (a) Uterine wall during metroplasty showing abundant fibrosis (white arrows), involving disperse greenish spheres (black arrows). (b) Spheres being detached from the uterine wall (black arrows), involved by fibrosis (white arrows)

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Figure 4: (a) Conglomerate of spheres removed from the uterine wall (black arrows), involved by fibrosis (white arrow). (b) Greenish smooth sphere with around 5 mm of diameter, extracted from the uterine wall (black arrow)

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This is a case of an unusual finding during hysteroscopy. It is important to highlight that metroplasty is not only and important procedure to improve reproductive outcomes in patients with uterine cavity defects but also to explore deeper layers of the uterine wall during hysteroscopy, up to the archimyometra, if an infiltrative disease such as adenomyosis is suspected.[6]

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form, the patient has given her consent for her images and other clinical information to be reported in the journal. The patient understands that her name and initial will not be published and due efforts will be made to conceal her identity, but anonymity cannot be guaranteed.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Munro MG, Critchley HO, Broder MS, Fraser IS; FIGO Working Group on Menstrual Disorders. FIGO classification system (PALM-COEIN) for causes of abnormal uterine bleeding in nongravid women of reproductive age. Int J Gynaecol Obstet 2011;113:3-13.  Back to cited text no. 1
    
2.
Kim A, Arabkhazaeli M, Ulrich A, Lerner V, Shin JH. Updates in uterine artery embolization for leiomyomas. Curr Opin Obstet Gynecol 2020;32:269-76.  Back to cited text no. 2
    
3.
McLucas B, Voorhees WD 3rd, Elliott S. Fertility after uterine artery embolization: A review. Minim Invasive Ther Allied Technol 2016;25:1-7.  Back to cited text no. 3
    
4.
Katsumori T, Miura H, Arima H, Hino A, Tsuji Y, Masuda Y, et al. Tris-acryl gelatin microspheres versus gelatin sponge particles in uterine artery embolization for leiomyoma. Acta Radiol 2017;58:834-41.  Back to cited text no. 4
    
5.
Hacking N, Maclean D, Vigneswaran G, Bryant T, Modi S. Uterine Fibroid Embolization (UFE) with optisphere: A prospective study of a new, spherical, resorbable embolic agent. Cardiovasc Intervent Radiol 2020;43:897-903.  Back to cited text no. 5
    
6.
Ferro J, Labarta E, Sanz C, Montoya P, Remohi J. Reproductive outcomes after hysteroscopic metroplasty for women with dysmorphic uterus and recurrent implantation failure. Facts Views Vis Obgyn 2018;10:63-8.  Back to cited text no. 6
    


    Figures

  [Figure 1], [Figure 2], [Figure 3], [Figure 4]



 

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